Motif ID: HOX{A6,A7,B6,B7}.p2

Z-value: 3.075


Transcription factors associated with HOX{A6,A7,B6,B7}.p2:

Gene SymbolEntrez IDGene Name
HOXA6 3203 homeobox A6
HOXA7 3204 homeobox A7
HOXB6 3216 homeobox B6
HOXB7 3217 homeobox B7



Activity profile for motif HOX{A6,A7,B6,B7}.p2.

activity profile for motif HOX{A6,A7,B6,B7}.p2


Sorted Z-values histogram for motif HOX{A6,A7,B6,B7}.p2

Sorted Z-values for motif HOX{A6,A7,B6,B7}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HOX{A6,A7,B6,B7}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_41579325 13.923


chr7_-_96471544 12.638 DLX6-AS1
DLX6 antisense RNA 1 (non-protein coding)
chr6_+_105511615 10.361 NM_001004317
 LIN28B
lin-28 homolog B (C. elegans)
chr8_-_114518194 9.889 NM_052900
NM_198123
 CSMD3

CUB and Sushi multiple domains 3

chr1_-_214963279 8.227 NM_001438
 ESRRG
estrogen-related receptor gamma
chr5_+_170668892 8.176 NM_021025
 TLX3
T-cell leukemia homeobox 3
chr18_-_28606839 7.504 NM_020805
 KLHL14
kelch-like 14 (Drosophila)
chr14_+_75907442 6.993 NM_004452
 ESRRB
estrogen-related receptor beta
chr2_-_200033445 6.891 SATB2
SATB homeobox 2
chr13_-_45323757 6.649 NM_198849
 SIAH3
seven in absentia homolog 3 (Drosophila)
chr10_+_83627422 6.573 NM_001165973
 NRG3
neuregulin 3
chr1_-_188713324 6.371 NM_199051
 FAM5C
family with sequence similarity 5, member C
chr14_-_94306104 6.249 NM_173849
 GSC
goosecoid homeobox
chr13_-_101852028 5.974 NM_175929
 FGF14
fibroblast growth factor 14
chr16_-_49742651 5.922 NM_002968
 SALL1
sal-like 1 (Drosophila)
chr12_+_79625538 5.828 NM_002469
 MYF6
myogenic factor 6 (herculin)
chr12_-_14024187 5.772 NM_000834
 GRIN2B
glutamate receptor, ionotropic, N-methyl D-aspartate 2B
chr10_+_68355797 5.766 NM_178011
 LRRTM3
leucine rich repeat transmembrane neuronal 3
chr12_-_16652202 5.742 NM_001001395
 LMO3
LIM domain only 3 (rhombotin-like 2)
chr14_+_61532293 5.579 NM_031914
 SYT16
synaptotagmin XVI

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 118 entries
Enrichment   P-value GO Accession GO Term
16.54 2.15e-06 GO:0021983 pituitary gland development
14.70 1.83e-08 GO:0021536 diencephalon development
11.88 2.04e-03 GO:0031128 developmental induction
11.88 2.04e-03 GO:0045168 cell-cell signaling involved in cell fate commitment
9.80 3.99e-02 GO:0048286 lung alveolus development
8.82 1.75e-02 GO:0071363 cellular response to growth factor stimulus
8.02 2.64e-06 GO:0042471 ear morphogenesis
8.02 8.69e-03 GO:0048663 neuron fate commitment
7.79 2.91e-03 GO:0070848 response to growth factor stimulus
7.47 3.24e-04 GO:0042472 inner ear morphogenesis
7.26 3.58e-05 GO:0048706 embryonic skeletal system development
7.15 1.89e-10 GO:0045165 cell fate commitment
6.88 5.80e-07 GO:0043583 ear development
6.85 8.87e-03 GO:0048704 embryonic skeletal system morphogenesis
6.79 2.52e-05 GO:0048839 inner ear development
6.51 4.50e-09 GO:0048562 embryonic organ morphogenesis
6.15 4.89e-09 GO:0030900 forebrain development
5.59 1.76e-02 GO:0048592 eye morphogenesis
5.59 4.79e-02 GO:2000027 regulation of organ morphogenesis
5.44 3.22e-06 GO:0009952 anterior/posterior pattern formation

Gene overrepresentation in compartment category:

Showing 1 to 9 of 9 entries
Enrichment   P-value GO Accession GO Term
4.47 2.73e-04 GO:0045211 postsynaptic membrane
3.38 1.35e-04 GO:0044456 synapse part
3.08 4.87e-05 GO:0045202 synapse
2.92 2.65e-02 GO:0005667 transcription factor complex
2.48 4.55e-04 GO:0030054 cell junction
2.41 3.79e-02 GO:0043005 neuron projection
1.69 4.16e-04 GO:0044459 plasma membrane part
1.41 3.17e-03 GO:0005886 plasma membrane
1.40 3.91e-03 GO:0071944 cell periphery

Gene overrepresentation in function category:

Showing 1 to 19 of 19 entries
Enrichment   P-value GO Accession GO Term
26.47 3.47e-02 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
26.47 3.47e-02 GO:0001012 RNA polymerase II regulatory region DNA binding
6.06 4.42e-02 GO:0003707 steroid hormone receptor activity
4.63 2.50e-24 GO:0043565 sequence-specific DNA binding
4.37 1.11e-05 GO:0000975 regulatory region DNA binding
4.37 1.11e-05 GO:0001067 regulatory region nucleic acid binding
4.37 1.11e-05 GO:0044212 transcription regulatory region DNA binding
4.24 8.43e-03 GO:0015276 ligand-gated ion channel activity
4.24 8.43e-03 GO:0022834 ligand-gated channel activity
4.12 1.41e-05 GO:0046982 protein heterodimerization activity
3.87 6.58e-04 GO:0010843 promoter binding
3.73 1.91e-22 GO:0001071 nucleic acid binding transcription factor activity
3.73 1.91e-22 GO:0003700 sequence-specific DNA binding transcription factor activity
3.56 1.37e-05 GO:0016563 transcription activator activity
3.52 6.26e-20 GO:0030528 transcription regulator activity
3.09 1.61e-03 GO:0016564 transcription repressor activity
2.28 4.04e-03 GO:0046983 protein dimerization activity
1.96 7.69e-09 GO:0003677 DNA binding
1.48 3.93e-03 GO:0003676 nucleic acid binding